APOPTOSIS CONTROLLED DEMOLITION AT THE CELLULAR LEVEL PDF

Metrics details Key Points Apoptosis is characterized by a series of dramatic perturbations to the cellular architecture that contribute not only to cell death, but also prepare cells for removal by phagocytes. Apoptotic cell death is orchestrated by members of the caspase family of cysteine proteases. Caspases target several hundred proteins for restricted proteolysis during this complex process of cell demolition. Although numerous caspase substrates have been linked to specific morphological features of apoptosis, it is likely that many proteins targeted by caspases contribute to death of the cell but have no significant impact on the phenotypic changes that are seen during this process. In other words, death by caspase activation probably results from many potentially lethal injuries rather than a single fatal blow. Multiple membrane alterations, most notably the externalization of phosphatidylserine, have been detected on apoptotic cells.

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Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Review of the literature. Article in Nature Williams J. Please enter a personalized message to the authors. Rho kinase regulates fragmentation and phagocytosis of lsvel cells. Apoptosis: controlled demolition at the cellular level — Semantic Scholar Martin Molecular cell Then, press proceed to send the authors a message. The primary goal of the generated response mechanism is to drive back the system to the former or to a new homeostatic state.

Each eukaryotic cell of multicellular organisms must be able to maintain its integrity by sensing both external and internal stimuli. Sign up for further access to Scientific Publications and Authors! By clicking accept or continuing ag use the site, you agree to the terms outlined in our Privacy PolicyTerms of Serviceand Dataset License. Only shared with authors of paper. From This Paper Figures and tables from this paper. References Publications referenced by this paper.

A novel role for microtubules in apoptotic chromatin dynamics and cellular fragmentation. Korsmeyer Howard Hughes Medical Institute. Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Controlled release of cisplatin and cancer cell apoptosis ta cisplatin encapsulated poly lactic-co-glycolic acid nanoparticles. Emily Lynam 5 Estimated H-index: Immunosuppressive effects of apoptotic cells.

Apoptosis: controlled demolition at the cellular level. Apoptosis is characterized by a series of dramatic perturbations to the cellular architecture that contribute not only to cell death, but also prepare cells for removal by phagocytes and prevent unwanted immune responses.

Role in Myocyte Apoptosis and Myocardial Remodeling. The modulatory effects of commensal neisseriae on upper respiratory tract infections. In this short report we discuss some novel and preliminary data gained by this approach on the crosstalk between life and edmolition decisions under cellular stress, to get a systems biological view of these networks. Establishing a blueprint for CEDdependent killing through identification of multiple substrates for this protease.

New data revealed that a systems-level crosstalk of molecular networks has an essential role in achieving the correct characteristic of the response. Are you looking for We can help you send a request to the authors directly.

Citations Publications citing this paper. Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics. Strategic disruption of nuclear pores structure, integrity and barrier for nuclear apoptosis. Ref Source Add To Collection.

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Apoptosis: controlled demolition at the cellular level

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Review of the literature. Article in Nature Williams J. Please enter a personalized message to the authors. Rho kinase regulates fragmentation and phagocytosis of lsvel cells. Apoptosis: controlled demolition at the cellular level — Semantic Scholar Martin Molecular cell Then, press proceed to send the authors a message. The primary goal of the generated response mechanism is to drive back the system to the former or to a new homeostatic state.

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Apoptosis: controlled demolition at the cellular level.

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